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Zfp281 Gene Detail
Summary
  • Symbol
    Zfp281
  • Name
    zinc finger protein 281
  • Synonyms
    MGC:70044, MGC:7737
  • Feature Type
    protein coding gene
  • IDs
    MGI:3029290
    NCBI Gene: 226442
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:136552639-136557791 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 59.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3029290
 protein coding gene Chr1:136552639-136558129 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016543
 protein coding gene Chr1:140482922-140488074 (+)
A/J MGP_AJ_G0016526
 protein coding gene Chr1:135136032-135141184 (+)
AKR/J MGP_AKRJ_G0016491
 protein coding gene Chr1:139164333-139169485 (+)
BALB/cJ MGP_BALBcJ_G0016486
 protein coding gene Chr1:135479094-135484246 (+)
C3H/HeJ MGP_C3HHeJ_G0016312
 protein coding gene Chr1:139260031-139265183 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016947
 protein coding gene Chr1:145482829-145487981 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014658
 protein coding gene Chr1:128247357-128252492 (+)
CAST/EiJ MGP_CASTEiJ_G0015892
 protein coding gene Chr1:138372127-138377283 (+)
CBA/J MGP_CBAJ_G0016285
 protein coding gene Chr1:150519394-150524546 (+)
DBA/2J MGP_DBA2J_G0016391
 protein coding gene Chr1:134132062-134137224 (+)
FVB/NJ MGP_FVBNJ_G0016390
 protein coding gene Chr1:132783138-132788290 (+)
LP/J MGP_LPJ_G0016462
 protein coding gene Chr1:141682650-141687802 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016415
 protein coding gene Chr1:156163362-156168514 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016983
 protein coding gene Chr1:138927711-138932863 (+)
PWK/PhJ MGP_PWKPhJ_G0015678
 protein coding gene Chr1:133185405-133190526 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015465
 protein coding gene Chr1:137918248-137923600 (+)
WSB/EiJ MGP_WSBEiJ_G0015955
 protein coding gene Chr1:138966288-138971440 (+)



Homology
more
  • Human Ortholog
    ZNF281, zinc finger protein 281
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF281, zinc finger protein 281
  • Synonyms
    GZP1, ZBP-99, ZBP99, ZNP-99
  • Links
    NCBI Gene ID: 23528
    neXtProt AC: NX_Q9Y2X9
    UniProt: Q9Y2X9

  • Chr Location
    1q32.1; chr1:200404940-200410056 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality between E7.5 and E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    66
  • cDNA Data
    10
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041483 Ensembl Gene Model | MGI Sequence Detail 5153 C57BL/6J ±  kb
    transcript ENSMUST00000047734 Ensembl | MGI Sequence Detail 4933 Not Applicable  
    polypeptide ENSMUSP00000039003 Ensembl | MGI Sequence Detail 893 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:346060 Huang X, et al., ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1. Dev Cell. 2024 Feb 26;59(4):465-481.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory