Foxl2<tm1Tre> Targeted Allele Detail MGI Mouse (MGI:3029503)

Foxl2^tm1Tre
Targeted Allele Detail

Summary

Symbol:	Foxl2^tm1Tre
Name:	forkhead box L2; targeted mutation 1, Mathias Treier
MGI ID:	MGI:3029503
Synonyms:	Foxl2^lacZ
Gene:	Foxl2 Location: Chr9:98837495-98840601 bp, + strand Genetic Position: Chr9, 51.41 cM, cytoband E4
Alliance:	Foxl2^tm1Tre page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:87737
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The sequence encoding amino acids 62-375 was replaced with an in frame nls-lacZ cassette followed by a floxed neomycin resistance gene. This deletes almost the entire the forkhead/winged-helix domain. The neomycin gene was subsequently excised. Western blot analysis of protein extracts from neonatal ovaries detected only lacZ fusion proteins and not the wild-type protein. (J:87737)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Foxl2 Mutation:	15 strains or lines available

References

Original:	J:87737 Schmidt D, et al., The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development. 2004 Feb;131(4):933-42
All:	7 reference(s)

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