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Adartm1Phs
Targeted Allele Detail
Summary
Symbol: Adartm1Phs
Name: adenosine deaminase, RNA-specific; targeted mutation 1, Peter H Seeburg
MGI ID: MGI:3029789
Synonyms: adar1-, adar1Delta7-9
Gene: Adar  Location: Chr3:89622329-89660753 bp, + strand  Genetic Position: Chr3, 39.19 cM, cytoband F2
Alliance: Adartm1Phs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87715
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A genomic fragment encompassing exons 7 through 9 was deleted by cre mediated recombination of an upstream floxed neo cassette and a downstream single loxP site. A single loxP site remains in intron 6. The deleted region encodes residues 707 through 870 of the interferon-inducible form of ADAR. (J:87715, J:142338)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adar Mutation:  72 strains or lines available
References
Original:  J:87715 Hartner JC, et al., Liver Disintegration in the Mouse Embryo Caused by Deficiency in the RNA-editing Enzyme ADAR1. J Biol Chem. 2004 Feb 6;279(6):4894-902
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory