About   Help   FAQ
Adartm1Knk
Targeted Allele Detail
Summary
Symbol: Adartm1Knk
Name: adenosine deaminase, RNA-specific; targeted mutation 1, Kazuko Nishikura
MGI ID: MGI:3032439
Synonyms: ADAR1flox
Gene: Adar  Location: Chr3:89622329-89660753 bp, + strand  Genetic Position: Chr3, 39.19 cM, cytoband F2
Alliance: Adartm1Knk page
Increased apoptosis in liver of Adartm1Knk/Adartm1Knk Speer6-ps1Tg(Alb-cre)21Mgn/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87714
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: Sequence encompassing exons 12 through 15 was flanked by single loxP sites in intron 11 and downstream of exon 15. (J:87714)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 124 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adar Mutation:  72 strains or lines available
References
Original:  J:87714 Wang Q, et al., Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J Biol Chem. 2004 Feb 6;279(6):4952-61
All:  17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory