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Mrgprx1 Gene Detail
Summary
  • Symbol
    Mrgprx1
  • Name
    MAS-related GPR, member X1
  • Synonyms
    MrgC11, Mrgprc11
  • Feature Type
    protein coding gene
  • IDs
    MGI:3033139
    NCBI Gene: 404242
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:47670719-47677345 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 31.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3033139
 protein coding gene Chr7:47670719-47677345 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032286
 protein coding gene Chr7:48599030-48600081 (-)
A/J MGP_AJ_G0032265
 protein coding gene Chr7:47881728-47887824 (-)
AKR/J MGP_AKRJ_G0032201
 protein coding gene Chr7:49064902-49073568 (-)
BALB/cJ MGP_BALBcJ_G0032277
 protein coding gene Chr7:47596764-47606423 (-)
C3H/HeJ MGP_C3HHeJ_G0031990
 protein coding gene Chr7:49421369-49428679 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032770
 protein coding gene Chr7:50880757-50890769 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029779
 protein coding gene Chr7:51168046-51169100 (-)
CAST/EiJ MGP_CASTEiJ_G0031318
 protein coding gene Chr7:40791638-40792692 (-)
CBA/J MGP_CBAJ_G0031955
 protein coding gene Chr7:52570812-52583399 (-)
DBA/2J MGP_DBA2J_G0032112
 protein coding gene Chr7:47151553-47161307 (-)
FVB/NJ MGP_FVBNJ_G0032066
 protein coding gene Chr7:47134278-47141176 (-)
LP/J MGP_LPJ_G0032193
 protein coding gene Chr7:49457414-49458468 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032103
 protein coding gene Chr7:51740039-51749792 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032787
 protein coding gene Chr7:48076395-48083575 (-)
PWK/PhJ MGP_PWKPhJ_G0031040
 protein coding gene Chr7:40603928-40604982 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030880
 protein coding gene Chr7:35915910-35923709 (-)
WSB/EiJ MGP_WSBEiJ_G0031438
 protein coding gene Chr7:48741508-48748100 (-)



Homology
more
  • Human Ortholog
    MRGPRX1, MAS related GPR family member X1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRGPRX1, MAS related GPR family member X1
  • Synonyms
    GPCR, MGRG2, MRGX1, SNSR4
  • Links
    NCBI Gene ID: 259249
    neXtProt AC: NX_Q96LB2
    UniProt: Q96LB2

  • Chr Location
    11p15.1,11; chr11:18933499-18939414 (-)  GRCh38
  • Human Ortholog
    MRGPRX3, MAS related GPR family member X3
  • Synonyms
    GPCR, MRGX3, SNSR1, SNSR2
  • Links
    NCBI Gene ID: 117195
    neXtProt AC: NX_Q96LB0
    UniProt: Q96LB0

  • Chr Location
    11p15.1; chr11:18120955-18138488 (+)  GRCh38
  • Human Ortholog
    MRGPRX4, MAS related GPR family member X4
  • Synonyms
    GPCR, MRGX4, SNSR6
  • Links
    NCBI Gene ID: 117196
    neXtProt AC: NX_Q96LA9
    UniProt: Q96LA9

  • Chr Location
    11p15.1; chr11:18172837-18174280 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display deceased itch response to tick peptides.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 404242 NCBI Gene Model | MGI Sequence Detail 6627 C57BL/6J ±  kb
transcript NM_207540 RefSeq | MGI Sequence Detail 1180 C57BL/6  
polypeptide Q8CIP3 UniProt | EBI | MGI Sequence Detail 322 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:71586 Dong X, et al., A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell. 2001 Sep 7;106(5):619-32
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory