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Tfap2atm2Will
Targeted Allele Detail
Summary
Symbol: Tfap2atm2Will
Name: transcription factor AP-2, alpha; targeted mutation 2, Trevor Williams
MGI ID: MGI:3038304
Synonyms: Alflox, AP-2alphalox, Tfap2afl
Gene: Tfap2a  Location: Chr13:40868778-40891852 bp, - strand  Genetic Position: Chr13, 20.01 cM, cytoband A5-B1
Alliance: Tfap2atm2Will page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88826
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: Exons 5 and 6 were flanked by single loxP sites in introns 4 and 6. A single frt site remained immediately upstream of the 3' loxP site after the excision of an frt-flanked neo cassette used for selection. (J:88826)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 22 assay results
6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 21 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tfap2a Mutation:  39 strains or lines available
References
Original:  J:88826 Brewer S, et al., Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects. Dev Biol. 2004 Mar 1;267(1):135-52
All:  19 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory