Klf5<tm1Rng> Targeted Allele Detail MGI Mouse (MGI:3038696)

Klf5^tm1Rng
Targeted Allele Detail

Summary

Symbol:	Klf5^tm1Rng
Name:	Kruppel-like transcription factor 5; targeted mutation 1, Ryozo Nagai
MGI ID:	MGI:3038696
Synonyms:	Klf5-
Gene:	Klf5 Location: Chr14:99536127-99550848 bp, + strand Genetic Position: Chr14, 49.43 cM, cytoband E2.1
Alliance:	Klf5^tm1Rng page

Pressure overload-induced cardiac hypertophy and fibrosis are reduced in Klf5^tm1Rng/Klf5⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:78275
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The 3' end of exon 2 and all of exon 3 were replaced with a neo cassette by homologous recombination. Western blot analysis showed decreased levels of protein in heterozygotes. (J:78275)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Klf5 Mutation:	37 strains or lines available

References

Original:	J:78275 Shindo T, et al., Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med. 2002 Aug;8(8):856-63
All:	7 reference(s)

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