Tlr9<M1Btlr> Chemically induced Allele Detail MGI Mouse (MGI:3038816)

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Tlr9^M1Btlr
Chemically induced Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Tlr9^M1Btlr
Name:	toll-like receptor 9; mutation 1, Bruce Beutler
MGI ID:	MGI:3038816
Synonyms:	CpG1, Tlr9^CpG1, unmethylated CpG-oligodeoxynucleotide unresponsive 1
Gene:	Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
Alliance:	Tlr9^M1Btlr page

Mutation
origin

Strain of Origin:	C57BL/6
Project Collection:	Beutler Mutagenetix

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: T to C transition at position 1496 results in a substitution of Leucine for Proline at amino acid 499. (J:88906)
Inheritance:		Semidominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Tlr9 Mutation:	66 strains or lines available

References

Original:	J:88906 Tabeta K, et al., Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3516-21
All:	13 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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