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Crlf2tm1Jni
Targeted Allele Detail
Summary
Symbol: Crlf2tm1Jni
Name: cytokine receptor-like factor 2; targeted mutation 1, James N Ihle
MGI ID: MGI:3039288
Synonyms: Tslpr-
Gene: Crlf2  Location: Chr5:109702575-109706859 bp, - strand  Genetic Position: Chr5, 53.24 cM
Alliance: Crlf2tm1Jni page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89031
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 3 and 4 were replaced with a neomycin resistance gene oriented in the direction opposite of endogenous gene transcription via homologous recombination. Northern blotting confirmed that no detectable transcript was produced from this allele in homozygous mutants. (J:89031)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crlf2 Mutation:  21 strains or lines available
References
Original:  J:89031 Carpino N, et al., Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development. Mol Cell Biol. 2004 Mar;24(6):2584-92
All:  62 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory