| Affected Systems |
|
|
|
|
|
behavior/neurological
|
|
√
|
|
|
lethargy
|
|
√
|
|
|
tremors
|
|
√
|
|
|
hunched posture
|
|
√
|
|
cardiovascular system
|
√
|
√
|
|
|
gastrointestinal hemorrhage
|
|
√
|
|
|
liver hemorrhage
|
|
√
|
|
|
decreased response of heart to induced stress
|
√
|
|
|
cellular
|
|
√
|
|
|
abnormal intestinal goblet cell morphology
|
|
√
|
|
|
increased hepatocyte apoptosis
|
|
√
|
|
craniofacial
|
|
√
|
|
|
abnormal incisor morphology
|
|
√
|
|
|
abnormal molar morphology
|
|
√
|
|
|
domed cranium
|
|
√
|
|
digestive/alimentary system
|
|
√
|
|
|
gastrointestinal hemorrhage
|
|
√
|
|
|
abnormal intestinal goblet cell morphology
|
|
√
|
|
|
abnormal Peyer's patch morphology
|
|
√
|
|
|
abnormal small intestine morphology
|
|
√
|
|
endocrine/exocrine glands
|
|
√
|
|
|
absent Meibomian glands
|
|
√
|
|
|
Harderian gland atrophy
|
|
√
|
|
growth/size/body
|
|
√
|
|
|
abnormal incisor morphology
|
|
√
|
|
|
abnormal molar morphology
|
|
√
|
|
|
decreased body size
|
|
√
|
|
hearing/vestibular/ear
|
|
√
|
|
|
deafness
|
|
√
|
|
|
increased susceptibility to otitis media
|
|
√
|
|
hematopoietic system
|
|
√
|
|
|
increased leukocyte cell number
|
|
√
|
|
|
increased granulocyte number
|
|
√
|
|
|
abnormal macrophage physiology
|
|
√
|
|
homeostasis/metabolism
|
√
|
|
|
|
decreased response of heart to induced stress
|
√
|
|
|
immune system
|
|
√
|
|
|
abnormal Peyer's patch morphology
|
|
√
|
|
|
increased leukocyte cell number
|
|
√
|
|
|
increased granulocyte number
|
|
√
|
|
|
abnormal macrophage physiology
|
|
√
|
|
|
abnormal lymph node morphology
|
|
√
|
|
|
increased inflammatory response
|
|
√
|
|
|
increased susceptibility to otitis media
|
|
√
|
|
|
keratoconjunctivitis sicca
|
|
√
|
|
integument
|
|
√
|
|
|
absent Meibomian glands
|
|
√
|
|
|
abnormal hair growth
|
|
√
|
|
|
alopecia
|
|
√
|
|
|
sparse hair
|
|
√
|
|
|
abnormal hair follicle development
|
|
√
|
|
|
sparse vibrissae
|
|
√
|
|
limbs/digits/tail
|
|
√
|
|
|
kinked tail
|
|
√
|
|
liver/biliary system
|
|
√
|
|
|
liver hemorrhage
|
|
√
|
|
|
increased hepatocyte apoptosis
|
|
√
|
|
mortality/aging
|
|
√
|
|
|
prenatal lethality, incomplete penetrance
|
|
√
|
|
reproductive system
|
|
√
|
|
|
decreased litter size
|
|
√
|
|
skeleton
|
|
√
|
N
|
|
skeleton phenotype
|
|
|
N
|
|
abnormal incisor morphology
|
|
√
|
|
|
abnormal molar morphology
|
|
√
|
|
|
domed cranium
|
|
√
|
|
vision/eye
|
|
√
|
|
|
keratoconjunctivitis sicca
|
|
√
|
|
|
abnormal eye morphology
|
|
√
|
|
|
abnormal eyelid morphology
|
|
√
|
|
|
absent Meibomian glands
|
|
√
|
|
|
blindness
|
|
√
|
|
|
dry eyes
|
|
√
|
|
Analysis Tools
