About   Help   FAQ
Syngap1 Gene Detail
Summary
  • Symbol
    Syngap1
  • Name
    synaptic Ras GTPase activating protein 1 homolog (rat)
  • Synonyms
    Syngap
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039785
    NCBI Gene: 240057
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:27160227-27191408 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 13.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    375 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039785
 protein coding gene Chr17:27160186-27191408 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023412
 protein coding gene Chr17:26165695-26203612 (+)
A/J MGP_AJ_G0023369
 protein coding gene Chr17:25371262-25403863 (+)
AKR/J MGP_AKRJ_G0023335
 protein coding gene Chr17:25504846-25537782 (+)
BALB/cJ MGP_BALBcJ_G0023374
 protein coding gene Chr17:25613288-25646854 (+)
C3H/HeJ MGP_C3HHeJ_G0023135
 protein coding gene Chr17:25880263-25913208 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023817
 protein coding gene Chr17:27271608-27307153 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021291
 protein coding gene Chr17:22781280-22813507 (+)
CAST/EiJ MGP_CASTEiJ_G0022636
 protein coding gene Chr17:25807631-25841637 (+)
CBA/J MGP_CBAJ_G0023109
 protein coding gene Chr17:28223541-28257500 (+)
DBA/2J MGP_DBA2J_G0023241
 protein coding gene Chr17:24933682-24966065 (+)
FVB/NJ MGP_FVBNJ_G0023210
 protein coding gene Chr17:24718743-24751744 (+)
LP/J MGP_LPJ_G0023318
 protein coding gene Chr17:26415629-26452354 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023228
 protein coding gene Chr17:27738587-27777855 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023858
 protein coding gene Chr17:25878102-25909572 (+)
PWK/PhJ MGP_PWKPhJ_G0022386
 protein coding gene Chr17:23732576-23764368 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022204
 protein coding gene Chr17:23914580-23947735 (+)
WSB/EiJ MGP_WSBEiJ_G0022699
 protein coding gene Chr17:25900673-25933909 (+)



Homology
more
  • Human Ortholog
    SYNGAP1, synaptic Ras GTPase activating protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYNGAP1, synaptic Ras GTPase activating protein 1
  • Synonyms
    MRD5, RASA1, RASA5, SYNGAP
  • Links
    NCBI Gene ID: 8831
    neXtProt AC: NX_Q96PV0
    UniProt: Q96PV0

  • Chr Location
    6p21.32; chr6:33418167-33453689 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Syngap1 mouse models; 1 with human SYNGAP1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 4 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit postnatal lethality, and by P3-P4, exhibit small body size and brain, reduced movement and do not feed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    17
  • cDNA Data
    4
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000067629 Ensembl Gene Model | MGI Sequence Detail 31182 C57BL/6J ±  kb
    transcript ENSMUST00000194598 Ensembl | MGI Sequence Detail 6011 Not Applicable  
    polypeptide ENSMUSP00000141686 Ensembl | MGI Sequence Detail 1340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 4
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 16
      Phenotypes 37
    • Earliest
      J:98903 Komiyama NH, et al., SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci. 2002 Nov 15;22(22):9721-32
    • Latest
      J:353560 Araki Y, et al., SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity. Science. 2024 Mar;383(6686):eadk1291
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory