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Ticam2tm1Aki
Targeted Allele Detail
Summary
Symbol: Ticam2tm1Aki
Name: TIR domain containing adaptor molecule 2; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3040182
Synonyms: Ticam2-, Tram_, TRAM-
Gene: Ticam2  Location: Chr18:46691298-46707600 bp, - strand  Genetic Position: Chr18, 24.65 cM
Alliance: Ticam2tm1Aki page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86256
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1.0 kb fragment encompassing the entire coding region of this single-exon gene was replaced with a neomycin selection cassette. Protein was undetected by Western blot analysis of immunoprecipitated lysates from homozygous mutant macrophages. (J:86256)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ticam2 Mutation:  25 strains or lines available
References
Original:  J:86256 Yamamoto M, et al., TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003 Nov;4(11):1144-50
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory