Tg(MtTGFA)100Lmb Transgene Detail MGI Mouse (MGI:3040889)

Tg(MtTGFA)100Lmb
Transgene Detail

Summary

Symbol:	Tg(MtTGFA)100Lmb
Name:	transgene insertion 100, Glenn Merlino
MGI ID:	MGI:3040889
Transgene:	Tg(MtTGFA)100Lmb Location: unknown
Alliance:	Tg(MtTGFA)100Lmb page

Transgene
origin

Strain of Origin:

FVB/N

Transgene
description

Transgene Type:

Transgenic (Humanized sequence, Inserted expressed sequence)

Mutation:

Insertion

Tg(MtTGFA)100Lmb expresses 1 gene

Mutation details: This transgene contains the inducible mouse metallothionein 1 promoter, cDNA of the wild-type allele of the human transforming growth factor alpha gene, and a human growth hormone polyadenylation signal. Line 100 carries ten copies of the transgene. (J:28452)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MtTGFA)100Lmb

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

Original:	J:28452 Jhappan C, et al., TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell. 1990 Jun 15;61(6):1137-46
All:	9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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