Bmp4<tm1Jfm> Targeted Allele Detail MGI Mouse (MGI:3041440)

Bmp4^tm1Jfm
Targeted Allele Detail

Summary

Symbol:	Bmp4^tm1Jfm
Name:	bone morphogenetic protein 4; targeted mutation 1, James F Martin
MGI ID:	MGI:3041440
Synonyms:	Bmp4^clc, Bmp4^floxneo
Gene:	Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
Alliance:	Bmp4^tm1Jfm page

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:89237
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP site was introduced upstream of exon 4 and another loxP site followed by a FRT-flanked neo was inserted downstream of exon 4. PCR was used to confirm recombination. (J:89237)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	99 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Bmp4 Mutation:	23 strains or lines available

References

Original:	J:89237 Liu W, et al., Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4489-94
All:	40 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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