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Gene Expression Data
Assay Details
Assay
Reference: J:89153 Ang SJ, et al., Spatial and temporal expression of Wnt and Dickkopf genes during murine lens development. Gene Expr Patterns. 2004 May;4(3):289-95
Assay type: RNA in situ
MGI Accession ID: MGI:3042136
Gene symbol: Dkk3
Gene name: dickkopf WNT signaling pathway inhibitor 3
Probe: Dkk3 cDNA1
Probe preparation: Antisense labelled with digoxigenin RNA
Assay notes: The lens development data is summarized in Table 1.
Results
Specimen Table 1, Dkks: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: lens placode Weak
Specimen Table 1, Dkks: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lens epithelium Strong
TS23: lens fiber Absent
Specimen 3, A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: future brain Weak 3A
TS15: head mesenchyme Weak 3A
Specimen 3, B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: lens pit Present 3B
TS17: optic cup Present Regionally restricted 3B Expression is in the retinal primordia.
TS17: brain Weak 3B
TS17: head mesenchyme Weak 3B
Specimen 3, B1: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: lens pit Present 3B1
TS17: optic cup Present Regionally restricted 3B1 Expression is in the retinal primordia.
TS17: brain Weak 3B1
TS17: head mesenchyme Weak 3B1
Specimen 3, C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cornea Present 3C
TS20: hyaloid vascular plexus Present 3C
TS20: lens vesicle Strong Regionally restricted 3C Expression is in the elongating primary fibers and the presumptive epithelial cells.
Specimen 3, C1: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cornea Present 3C1
TS20: hyaloid vascular plexus Present 3C1
TS20: lens vesicle Strong Regionally restricted 3C1 Expression is in the elongating primary fibers and the presumptive epithelial cells.
Specimen 3, D: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lens epithelium Strong 3D
TS22: lens fiber Strong Regionally restricted 3D Expression is in the less mature elongating fibers. Expression is absent in the most mature primary fibers in the center of the lens.
TS22: cornea epithelium Strong 3D
TS22: cornea Strong Regionally restricted 3D Expression is in the endothelium.
TS22: cornea stroma Present 3D
TS22: eye Present Regionally restricted 3D Expression in the optic cup is in the margin of cells destined to form the ciliary and iridial epithelia and the developing ganglion cell layer.
TS22: hyaloid vascular plexus Weak 3D
Specimen 3, D1: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lens epithelium Strong 3D1
TS22: lens fiber Strong Regionally restricted 3D1 Expression is in the less mature elongating fibers. Expression is absent in the most mature primary fibers in the center of the lens.
TS22: cornea epithelium Strong 3D1
TS22: cornea Strong Regionally restricted 3D1 Expression is in the endothelium.
TS22: cornea stroma Present 3D1
TS22: eye Present Regionally restricted 3D1 Expression in the optic cup is in the margin of cells destined to form the ciliary and iridial epithelia and the developing ganglion cell layer.
TS22: hyaloid vascular plexus Weak 3D1
Specimen 3, E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lens epithelium Strong 3E
TS26: lens fiber Strong Regionally restricted 3E Expression is in the less mature elongating fibers. Expression is absent in the most mature primary fibers in the center of the lens.
TS26: cornea endothelium Strong 3E
TS26: cornea epithelium Strong 3E
TS26: cornea stroma Present 3E
TS26: eye Present Regionally restricted 3E Expression in the optic cup is in the margin of cells destined to form the ciliary and iridial epithelia, the ciliary/iridial stroma, and the developing ganglion cell layer.
TS26: hyaloid vascular plexus Weak 3E
Specimen 3, E1: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: lens epithelium Strong 3E1
TS26: lens fiber Strong Regionally restricted 3E1 Expression is in the less mature elongating fibers. Expression is absent in the most mature primary fibers in the center of the lens.
TS26: cornea endothelium Strong 3E1
TS26: cornea epithelium Strong 3E1
TS26: cornea stroma Present 3E1
TS26: eye Present Regionally restricted 3E1 Expression in the optic cup is in the margin of cells destined to form the ciliary and iridial epithelia, the ciliary/iridial stroma, and the developing ganglion cell layer.
TS26: hyaloid vascular plexus Weak 3E1
Specimen 3, F: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: lens epithelium Strong 3F
TS27: lens Strong Regionally restricted 3F Expression is in the equatorial region and is absent in cortical fiber cells.
Specimen 3, F1: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: lens epithelium Strong 3F1
TS27: lens Strong Regionally restricted 3F1 Expression is in the equatorial region and is absent in cortical fiber cells.
TS27: ciliary body Present 3F1
TS27: iris Present 3F1
Specimen 3, G: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: lens epithelium Strong 3G
TS28: lens Strong Regionally restricted 3G Expression is in the equatorial region and is absent in cortical fiber cells.
Specimen 3, G1: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: lens epithelium Strong 3G1
TS28: lens Strong Regionally restricted 3G1 Expression is in the equatorial region and is absent in cortical fiber cells.
Specimen 3, H: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: lens epithelium Present Graded 3H Expression is weaker in the central epithelium.
TS28: lens Present Regionally restricted 3H Expression is in the equatorial region and is absent in cortical fiber cells.
Specimen 3, H1: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: lens epithelium Present Graded 3H1 Expression is weaker in the central epithelium.
TS28: lens Present Regionally restricted 3H1 Expression is in the equatorial region and is absent in cortical fiber cells.
Specimen Not shown: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: cornea endothelium Strong
TS27: cornea epithelium Strong
Specimen Not shown: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: cornea endothelium Strong
TS28: cornea epithelium Strong
Specimen Not shown: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: cornea endothelium Strong
TS28: cornea epithelium Strong
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/17/2024
MGI 6.24 		The Jackson Laboratory