Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Amhr2tm3(cre)Bhr
Name:	anti-Mullerian hormone type 2 receptor; targeted mutation 3, Richard R Behringer
MGI ID:	MGI:3042214
Synonyms:	Amh-mis-Cre, Amhr2-cre, Amhr2cre, Amhr-2/Cre, Amhr2cre, Amhr2-IRES-Cre(Bhr)
Gene:	Amhr2  Location: Chr15:102353802-102363068 bp, + strand  Genetic Position: Chr15, 57.58 cM
Alliance:	Amhr2tm3(cre)Bhr page

Germline Transmission:	Earliest citation of germline transmission: J:89999
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Amhr2tm3(cre)Bhr expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Amhr2 (MGI:105062)   Mutation details: A cassette containing IRES-cre and an FRT-flanked neo cassette was inserted into exon 5 of the endogenous gene. Expression of functional cre recombinase was detected in both male and female gonads and in the Mullerian duct. Based on phenotypic similarity to previously described Amhr2 deficient mice, this allele is putatively null. (J:89999, J:118270)

Activity:	Tissue activity of this recombinase allele
Driver:	Amhr2 (mouse) Summary of all recombinase alleles driven by Amhr2. Comparative matrix view of recombinase activities Alliance mouse Amhr2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	187 assay results 8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

List all tumor models in MMHCdb carrying Amhr2tm3(cre)Bhr

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Amhr2 Mutation:	29 strains or lines available

Original:	J:89999 Jamin SP, et al., Requirement of Bmpr1a for Mullerian duct regression during male sexual development. Nat Genet. 2002 Nov;32(3):408-10
All:	168 reference(s)