About   Help   FAQ
Bmp10tm1Shou
Targeted Allele Detail
Summary
Symbol: Bmp10tm1Shou
Name: bone morphogenetic protein 10; targeted mutation 1, Weinian Shou
MGI ID: MGI:3042354
Synonyms: BMP10-
Gene: Bmp10  Location: Chr6:87405976-87411494 bp, + strand  Genetic Position: Chr6, 37.96 cM, cytoband D2
Alliance: Bmp10tm1Shou page
Absent vitelline vessels in the yolk sac, stalled vascular development at the primary capillary plexus stage, and arteriovenous malformation in Bmp10tm1Shou/Bmp10tm1Shou embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89476
Parent Cell Line:  CCE916 (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 1 and 2 were deleted and replaced with a PGK-neo cassette via homologous recombination. RT-PCR confirmed the absence of expression in homozygotes. (J:89476)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp10 Mutation:  23 strains or lines available
References
Original:  J:89476 Chen H, et al., BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004 May;131(9):2219-31
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory