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Icam5tm1(cre)Mmsh
Targeted Allele Detail
Summary
Symbol: Icam5tm1(cre)Mmsh
Name: intercellular adhesion molecule 5, telencephalin; targeted mutation 1, Masayoshi Mishina
MGI ID: MGI:3042494
Synonyms: TLCN-Cre
Gene: Icam5  Location: Chr9:20943372-20950331 bp, + strand  Genetic Position: Chr9, 7.7 cM, cytoband A3
Alliance: Icam5tm1(cre)Mmsh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89407
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Icam5tm1(cre)Mmsh expression driven by 1 gene
 
Mutation details: Cre recombinase and neomycin resistance genes replaced an 82 bp exonic sequence encoding the start codon and the following 69 bp of intronic sequence. In situ hybridization demonstrated the absence of normal RNA and Western blot confirmed absence of normal protein from mutant mice. (J:89407)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Icam5 (mouse)
Summary of all recombinase alleles driven by Icam5.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icam5 Mutation:  28 strains or lines available
References
Original:  J:89407 Nakamura K, et al., Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule. Eur J Neurosci. 2001 Jan;13(1):179-89
All:  36 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
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