Nbl1<tm1Saki> Targeted Allele Detail MGI Mouse (MGI:3042574)

About Help FAQ

Nbl1^tm1Saki
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Nbl1^tm1Saki
Name:	NBL1, DAN family BMP antagonist; targeted mutation 1, S Sakiyama
MGI ID:	MGI:3042574
Synonyms:	Dan-
Gene:	Nbl1 Location: Chr4:138809595-138820304 bp, - strand Genetic Position: Chr4, 70.57 cM, cytoband D3
Alliance:	Nbl1^tm1Saki page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:89353
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A 2.5 kb fragment including exons 2 and 3 was replaced with an MC1-Neo cassette. RT-PCR confirmed the absence of RNA expression in homozygotes. (J:89353)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Nbl1 Mutation:	16 strains or lines available

References

Original:	J:89353 Ohtori S, et al., Reduced inflammatory pain in mice deficient in the differential screening-selected gene aberrative in neuroblastoma. Mol Cell Neurosci. 2004 Mar;25(3):504-14
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24