Gnas<tm3Lsw> Targeted Allele Detail MGI Mouse (MGI:3043361)

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Gnas^tm3Lsw
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Gnas^tm3Lsw
Name:	GNAS complex locus; targeted mutation 3, Lee S Weinstein
MGI ID:	MGI:3043361
Synonyms:	E1^fl, GSalpha^floxed
Gene:	Gnas Location: Chr2:174126113-174188537 bp, + strand Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
Alliance:	Gnas^tm3Lsw page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:89923
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: LoxP sites were inserted at -1601 bp and +419 relative to translation start site, surrounding Gs-alpha exon 1. (J:89923)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gnas Mutation:	54 strains or lines available

References

Original:	J:89923 Sakamoto A, et al., Tissue-specific imprinting of the G protein Gsalpha is associated with tissue-specific differences in histone methylation. Hum Mol Genet. 2004 Apr 15;13(8):819-28
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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