Tg(Wap-rtTA-cre)10Whl
Transgene Detail
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| Symbol: |
Tg(Wap-rtTA-cre)10Whl |
| Name: |
transgene insertion 10, Wen-Hwa Lee |
| MGI ID: |
MGI:3043456 |
| Synonyms: |
TgWAPrtTACre, Wap-cre, WAPCrec, Wap-rtTA-Cre |
| Transgene: |
Tg(Wap-rtTA-cre)10Whl Location: unknown
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| Alliance: |
Tg(Wap-rtTA-cre)10Whl page
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| Transgene Type: |
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Transgenic (Recombinase, Transactivator) |
| Mutation: |
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Insertion
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Tg(Wap-rtTA-cre)10Whl expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Wap |
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Mutation details: Sequence encoding reverse tetracycline-controlled transactivator (rtTA) was placed under control of the whey acidic protein promoter and in cis configuration with sequence encoding cre recombinase adjoined to an rtTA-inducible CMV promoter. Initial reporter analysis showed cre activity to be completely doxycycline dependent and restricted to the mammary epithelial cells. In contrast, subsequent activity analysis in J:90247 showed doxycycline independent cre activity in a variety of tissues including the mammary gland, brain, liver, and spleen; putatively due to a modification of the transgene and/or the unstable nature of transgene copy number.
(J:69330)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Wap
(species not specified)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:69330 Utomo AR, et al., Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice. Nat Biotechnol. 1999 Nov;17(11):1091-6 |
| All: |
12 reference(s) |
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Analysis Tools
