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Gja10tm1Kwi
Targeted Allele Detail
Summary
Symbol: Gja10tm1Kwi
Name: gap junction protein, alpha 10; targeted mutation 1, Klaus Willecke
MGI ID: MGI:3043946
Synonyms: Cx57-, Cx57lacZ
Gene: Gja10  Location: Chr4:32596960-32602760 bp, - strand  Genetic Position: Chr4, 14.25 cM
Alliance: Gja10tm1Kwi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90294
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A portion of exon 2 encoding amino acids 1 through 346 was replaced with a cassette containing lacZ and neo genes by homologous recombination. Northern blot analyses of retina confirmed the absence of RNA in homozygous mutant mice. The expression pattern of lacZ was similar to that of the endogenous gene. (J:90294, J:128358)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gja10 Mutation:  24 strains or lines available
References
Original:  J:90294 Hombach S, et al., Functional expression of connexin57 in horizontal cells of the mouse retina. Eur J Neurosci. 2004 May;19(10):2633-40
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory