Twist2<tm1(cre)Dor> Targeted Allele Detail MGI Mouse (MGI:3044412)

Twist2^tm1(cre)Dor
Targeted Allele Detail

Summary

Symbol:	Twist2^tm1(cre)Dor
Name:	twist basic helix-loop-helix transcription factor 2; targeted mutation 1, David M Ornitz
MGI ID:	MGI:3044412
Synonyms:	Dermo1^cre, Dermo-1^Cre, Dermo1-Cre, Dermo1Cre, Dermo^cre, DM1-Cre, twist-2^-, Twist2^tm1(cre)Eno
Gene:	Twist2 Location: Chr1:91729183-91775750 bp, + strand Genetic Position: Chr1, 46.24 cM
Alliance:	Twist2^tm1(cre)Dor page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:81485
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutations:

Insertion, Intragenic deletion

Twist2^tm1(cre)Dor expression driven by 1 gene

Mutation details: Exon 1 was replaced with a cre recombinase gene and an FRT-flanked neo cassette. Southern blot analysis confirmed recombination. Cre was expressed in the developing skeleton, specifically in mesenchymal condensations giving rise to both osteoblast and chondrocyte lineages. (J:90391)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Twist2 (mouse) Summary of all recombinase alleles driven by Twist2. Comparative matrix view of recombinase activities Alliance mouse Twist2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	60 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Twist2 Mutation:	10 strains or lines available

References

Original:	J:81485 Sosic D, et al., Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell. 2003 Jan 24;112(2):169-80
All:	84 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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