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Edn1tm1Ywa
Targeted Allele Detail
Summary
Symbol: Edn1tm1Ywa
Name: endothelin 1; targeted mutation 1, Masashi Yanagisawa
MGI ID: MGI:3044563
Synonyms: ET-1flox
Gene: Edn1  Location: Chr13:42454952-42461466 bp, + strand  Genetic Position: Chr13, 20.82 cM
Alliance: Edn1tm1Ywa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90390
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A loxP site was inserted upstream of exon 2, and a neo-thymidine kinase selection cassette with a 3' loxP site was inserted downstream of exon 2. Southern blot and RT-PCR indicate presence of recombinant transcript. (J:90390)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 57 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Edn1 Mutation:  26 strains or lines available
References
Original:  J:90390 Shohet RV, et al., Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2088-93
All:  24 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory