Fgfr2<tm1Dor> Targeted Allele Detail MGI Mouse (MGI:3044679)

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Fgfr2^tm1Dor
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Fgfr2^tm1Dor
Name:	fibroblast growth factor receptor 2; targeted mutation 1, David M Ornitz
MGI ID:	MGI:3044679
Synonyms:	Fgfr2^delta8-10lox, Fgfr2^f, Fgfr2^fl, Fgfr2^flox, Fgfr2^Lox, Fgfr2^loxP
Gene:	Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
Alliance:	Fgfr2^tm1Dor page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:90391
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: Exons 8 through 10 were flanked by a single loxP site in intron 7 and an FRT-flanked neo cassette with a 3' loxP site in intron 10. (J:90391)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	129 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:	90 strains or lines available

References

Original:	J:90391 Yu K, et al., Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development. 2003 Jul;130(13):3063-74
All:	160 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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