About   Help   FAQ
Mfge8tm1Osa
Targeted Allele Detail
Summary
Symbol: Mfge8tm1Osa
Name: milk fat globule EGF and factor V/VIII domain containing; targeted mutation 1, Shigekazu Nagata
MGI ID: MGI:3044898
Synonyms: MFG-E8-
Gene: Mfge8  Location: Chr7:78783516-78798808 bp, - strand  Genetic Position: Chr7, 44.9 cM
Alliance: Mfge8tm1Osa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90633
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomysin resistance cassette replaced exons 4-6. Southern blot confirmed recombination in mutant tails. Western blot analysis showed no protein expression in macrophages. (J:90633)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mfge8 Mutation:  23 strains or lines available
References
Original:  J:90633 Hanayama R, et al., Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science. 2004 May 21;304(5674):1147-50
All:  40 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory