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Mfge8tm1Osa
Targeted Allele Detail
Summary
Symbol: Mfge8tm1Osa
Name: milk fat globule EGF and factor V/VIII domain containing; targeted mutation 1, Shigekazu Nagata
MGI ID: MGI:3044898
Synonyms: MFG-E8-
Gene: Mfge8  Location: Chr7:78783516-78798808 bp, - strand  Genetic Position: Chr7, 44.9 cM
Alliance: Mfge8tm1Osa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90633
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomysin resistance cassette replaced exons 4-6. Southern blot confirmed recombination in mutant tails. Western blot analysis showed no protein expression in macrophages. (J:90633)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mfge8 Mutation:  23 strains or lines available
References
Original:  J:90633 Hanayama R, et al., Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science. 2004 May 21;304(5674):1147-50
All:  40 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory