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Hes7tm2Kag
Targeted Allele Detail
Summary
Symbol: Hes7tm2Kag
Name: hes family bHLH transcription factor 7; targeted mutation 2, Ryoichiro Kageyama
MGI ID: MGI:3046536
Synonyms: Hes7118G, Hes7tm2Rka
Gene: Hes7  Location: Chr11:69011230-69014881 bp, + strand  Genetic Position: Chr11, 42.38 cM
Alliance: Hes7tm2Kag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91127
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutation:    Single point mutation
 
Mutation details: An A to G transition mutation was introduced at nucleotide residue 118 in exon 1 converting a lysine into an arginine (K14R). This mutation increased the half-life of the protein from about 22 minutes to about 30 minutes without knocking out repressor activity. In situ analysis indicates that the mutant protein is expressed. (J:91127)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hes7 Mutation:  22 strains or lines available
References
Original:  J:91127 Hirata H, et al., Instability of Hes7 protein is crucial for the somite segmentation clock. Nat Genet. 2004 Jul;36(7):750-4
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory