Capn3<Gt(OST141731)Lex> Gene trapped Allele Detail MGI Mouse (MGI:3046866)

Capn3^{Gt(OST141731)Lex}
Gene trapped Allele Detail

Summary

Symbol:	Capn3^{Gt(OST141731)Lex}
Name:	calpain 3; gene trap OST141731, Lexicon Genetics
MGI ID:	MGI:3046866
Synonyms:	C3KO, Capn3^{Gt(neo)453Lex}, Capn3^{Gt(neo-btk)1Spc}, Capn3-^tm1Spc
Gene:	Capn3 Location: Chr2:120294074-120335400 bp, + strand Genetic Position: Chr2, 60.31 cM
Alliance:	Capn3^{Gt(OST141731)Lex} page

Mutation
origin

Mutant Cell Line:	OST141731
Germline Transmission:	Earliest citation of germline transmission: J:91206
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector

Mutation details: A gene trap vector containing a neo-btk disrupted the gene by integrating into intron 1, thereby introducing premature stop codons after transcription. No gene products were detected by RT-PCR, including any splice variants. Western blot confirmed absence of full-length protein and fusion proteins of any size. (J:91206)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Capn3 Mutation:	49 strains or lines available

References

Original:	J:91206 Kramerova I, et al., Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro. Hum Mol Genet. 2004 Jul 1;13(13):1373-88
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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