Ptk7Gt(Betageo)1Matl
Gene trapped Allele Detail
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| Symbol: |
Ptk7Gt(Betageo)1Matl |
| Name: |
PTK7 protein tyrosine kinase 7; gene trap 1, Marc Tessier-Lavigne |
| MGI ID: |
MGI:3046905 |
| Synonyms: |
Ptk7XST87, XST87 |
| Gene: |
Ptk7 Location: Chr17:46875397-46940430 bp, - strand Genetic Position: Chr17, 22.9 cM, cytoband B3
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| Alliance: |
Ptk7Gt(Betageo)1Matl page
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| Mutant Cell Line: |
XST087 |
| Germline Transmission: |
Earliest citation of germline transmission:
J:91298
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Gene trapped (Null/knockout, Reporter) |
| Mutation: |
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Insertion of gene trap vector
Vector: pGT1TMpfs
Vector Type: secretory trap
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Mutation details: A gene trap vector including a beta-galactosidase and neo was inserted into intron 2. The allele is predicted to result in a null or a severely hypomorphic mutation, with the in-frame fusion of the first 114 amino acids to the transmembrane Beta-gal and neo construct. A transcript with the expected size for the fused RNA was detected in Northern blot of mutant brain lysates, and Western blot showed a peptide of the size of the predicted fusion product instead of the two peptides detected in wild-type brain lysates.
(J:91298)
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| Sequence Tags: |
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Sequence tag details (1 tag)
| Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
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| Genome Context: |
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Genome Browser view of this mutation
37 gene trap insertions have trapped this gene
View all gene trap sequence tags in this region
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ptk7 Mutation: |
60 strains or lines available
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All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
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| Original: |
J:91298 Lu X, et al., PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature. 2004 Jul 1;430(6995):93-8 |
| All: |
9 reference(s) |
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Analysis Tools
