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Cacna1ctm1Jst
Targeted Allele Detail
Summary
Symbol: Cacna1ctm1Jst
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1, Jorg Striessnig
MGI ID: MGI:3047071
Synonyms: Cav1.2DHP-
Gene: Cacna1c  Location: Chr6:118564201-119173851 bp, - strand  Genetic Position: Chr6, 55.86 cM
Alliance: Cacna1ctm1Jst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91092
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details: A floxed neo was inserted upstream of a mutagenized exon 24 containing T1066Y, that encodes regions of the alpha 1 subunit. Crossing with deleter mice excised the floxed neo in the germ line, leaving the mutation in exon 24. Southern blot confirmed recombination and Western blot of brain and heart membranes showed no affects of the mutation on gene expression density. (J:91092)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1c Mutation:  144 strains or lines available
References
Original:  J:91092 Sinnegger-Brauns MJ, et al., Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels. J Clin Invest. 2004 May;113(10):1430-9
All:  10 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory