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Dnmt3atm3.1Enl
Targeted Allele Detail
Summary
Symbol: Dnmt3atm3.1Enl
Name: DNA methyltransferase 3A; targeted mutation 3.1, En Li
MGI ID: MGI:3047552
Synonyms: Dnmt3a2lox, Dnmt3a2loxP, Dnmt3afl, Dnmt3aflox
Gene: Dnmt3a  Location: Chr12:3856007-3964443 bp, + strand  Genetic Position: Chr12, 1.99 cM, cytoband A2-A3
Alliance: Dnmt3atm3.1Enl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91108
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: This allele was created by crossing Dnmt3atm3Enl with Ella-cre mice, thereby excising the floxed neo and leaving exon 19 floxed. Exon 19 encodes the conserved PC motif of the catalytic domain. (J:91108)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dnmt3a Mutation:  139 strains or lines available
References
Original:  J:91108 Kaneda M, et al., Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature. 2004 Jun 24;429(6994):900-3
All:  98 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory