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Klf2tm1Ling
Targeted Allele Detail
Summary
Symbol: Klf2tm1Ling
Name: Kruppel-like transcription factor 2 (lung); targeted mutation 1, Jerry B Lingrel
MGI ID: MGI:3047647
Synonyms: LKLF-
Gene: Klf2  Location: Chr8:73072906-73075498 bp, + strand  Genetic Position: Chr8, 34.99 cM, cytoband C1
Alliance: Klf2tm1Ling page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51402
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: An expression cassette of the hypoxanthine phosphoriboyltrasferase (HPRT) gene replaced the promoter region, and sequences encoding the transcription activation domain and part of the DNA binding domain of the gene. Northern and RT-PCR analysis showed that a null allele was obtained. (J:51402)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 28 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf2 Mutation:  12 strains or lines available
References
Original:  J:51402 Wani MA, et al., Loss of LKLF function results in embryonic lethality in mice. Transgenic Res. 1998 Jul;7(4):229-38
All:  17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory