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Gabra6tm2(cre)Wwis
Targeted Allele Detail
Summary
Symbol: Gabra6tm2(cre)Wwis
Name: gamma-aminobutyric acid type A receptor subunit alpha 6; targeted mutation 2, W Wisden
MGI ID: MGI:3047798
Synonyms: delta alpha6Cre
Gene: Gabra6  Location: Chr11:42197264-42211899 bp, - strand  Genetic Position: Chr11, 25.03 cM
Alliance: Gabra6tm2(cre)Wwis page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91624
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Gabra6tm2(cre)Wwis expression driven by 1 gene
 
Mutation details: Exon 8 was disrupted by insertion, via homologous recombination, of a TAG3 IRES-nlsCre-neo cassette, which contains stop codons in all reading frames followed by an encephalomyelocarditis virus internal ribosome entry site (IRES), the coding sequence for Cre recombinase flanked by the nuclear localization sequence and polyadenylation signal from SV40, and a neomycin resistance gene driven by the HSV promoter. Cre was shown, both by immunohistochemistry and by X-gal staining of brains of adult F1 progeny from a cross to a beta-galactosidase expressing Cre reporter strain, to be expressed uniformly in nuclei of all cells of the granule cell layer and, additionally, in a few Purkinje cells and in some small cells in the molecular layer. (J:91624)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gabra6 (mouse)
Summary of all recombinase alleles driven by Gabra6.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gabra6 Mutation:  39 strains or lines available
References
Original:  J:91624 Aller MI, et al., Cerebellar granule cell Cre recombinase expression. Genesis. 2003 Jun;36(2):97-103
All:  24 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory