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Tg(HBB-cre)27053Kpe
Transgene Detail
Summary
Symbol: Tg(HBB-cre)27053Kpe
Name: transgene insertion 27053, Kenneth Peterson
MGI ID: MGI:3050350
Synonyms: Tg(HBB-cre)27053Tpa
Transgene: Tg(HBB-cre)27053Kpe  Location: unknown  
Alliance: Tg(HBB-cre)27053Kpe page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(HBB-cre)27053Kpe expression driven by 1 gene
 
Mutation details: This transgene expresses Cre recombinase under the control of a human beta-globin gene promoter and a beta-globin locus control region (LCR). The inserted copy number was determined to be 2. Expression of Cre was determined by crosses to a reporter strain, and was shown to be present in the erythroid compartment throughout development, including the yolk sac during primitive erythropoiesis, the liver during fetal definitive erythropoiesis and the bone marrow during adult definitive erythropoiesis. Cre activity was also noted in the peripheral circulation during development, in the adult liver and in some megakaryocytes. No expression in the germ line was detected. (J:89725)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: HBB (human)
Summary of all recombinase alleles driven by HBB.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:89725 Peterson KR, et al., Transgenic Cre expression mice for generation of erythroid-specific gene alterations. Genesis. 2004 May;39(1):1-9
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
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