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Akap6 Gene Detail
Summary
  • Symbol
    Akap6
  • Name
    A kinase anchor protein 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:3050566
    NCBI Gene: 238161
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:52746166-53202382 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 22.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13065 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3050566
 protein coding gene Chr12:52745371-53202382 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019733
 protein coding gene Chr12:51541190-52005671 (+)
A/J MGP_AJ_G0019695
 protein coding gene Chr12:49713086-50171530 (+)
AKR/J MGP_AKRJ_G0019666
 protein coding gene Chr12:51214621-51669357 (+)
BALB/cJ MGP_BALBcJ_G0019673
 protein coding gene Chr12:49993147-50447646 (+)
C3H/HeJ MGP_C3HHeJ_G0019476
 protein coding gene Chr12:51313674-51783327 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020121
 protein coding gene Chr12:53134999-53608819 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017744
 protein coding gene Chr12:48085590-48513340 (+)
CAST/EiJ MGP_CASTEiJ_G0019029
 protein coding gene Chr12:46359708-46821007 (+)
CBA/J MGP_CBAJ_G0019448
 protein coding gene Chr12:54960750-55456337 (+)
DBA/2J MGP_DBA2J_G0019562
 protein coding gene Chr12:49586746-50034872 (+)
FVB/NJ MGP_FVBNJ_G0019551
 protein coding gene Chr12:49020066-49465461 (+)
LP/J MGP_LPJ_G0019634
 protein coding gene Chr12:51585912-52084147 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019587
 protein coding gene Chr12:56613415-57113138 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020159
 protein coding gene Chr12:50726943-51182231 (+)
PWK/PhJ MGP_PWKPhJ_G0018796
 protein coding gene Chr12:44166614-44605430 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018590
 protein coding gene Chr12:45305285-45768179 (+)
WSB/EiJ MGP_WSBEiJ_G0019080
 protein coding gene Chr12:51198496-51655001 (+)



Homology
more
  • Human Ortholog
    AKAP6, A-kinase anchoring protein 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKAP6, A-kinase anchoring protein 6
  • Synonyms
    ADAP100, ADAP6, AKAP100, mAKAP, PRKA6
  • Links
    NCBI Gene ID: 9472
    neXtProt AC: NX_Q13023
    UniProt: Q13023

  • Chr Location
    14q12; chr14:32329298-32837684 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human AKAP6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene results in partial embryonic lethality; surviving homozygotes display a decreased body weight, craniofacial defects and reduced viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    50
  • cDNA Data
    10
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061603 Ensembl Gene Model | MGI Sequence Detail 456217 C57BL/6J ±  kb
    transcript ENSMUST00000095737 Ensembl | MGI Sequence Detail 14847 Not Applicable  
    polypeptide ENSMUSP00000093406 Ensembl | MGI Sequence Detail 2307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144849
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:198914 Kapiloff MS, et al., mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci. 2001 Sep;114(Pt 17):3167-76
    • Latest
      J:358347 Dias AP, et al., Tail-anchored membrane protein SLMAP3 is essential for targeting centrosomal proteins to the nuclear envelope in skeletal myogenesis. Open Biol. 2024 Oct;14(10):240094
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory