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Plxnd1tm1Joe
Targeted Allele Detail
Summary
Symbol: Plxnd1tm1Joe
Name: plexin D1; targeted mutation 1, Jonathan A Epstein
MGI ID: MGI:3050678
Synonyms: plexinD1-
Gene: Plxnd1  Location: Chr6:115931772-115971966 bp, - strand  Genetic Position: Chr6, 53.72 cM
Alliance: Plxnd1tm1Joe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91658
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The first coding exon, containing the sema domain, was replaced with a floxed neo. Southern blot demonstrated correct targeting. In situ hybridization and immunohistochemistry indicated lack of transcript and protein, respectively, in mutant embryos and hearts. (J:91658)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plxnd1 Mutation:  87 strains or lines available
References
Original:  J:91658 Gitler AD, et al., PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell. 2004 Jul;7(1):107-16
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory