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Mrtfb Gene Detail
Summary
  • Symbol
    Mrtfb
  • Name
    myocardin related transcription factor B
  • Synonyms
    Gt4-1, MGC:41582, Mkl2, Mrtfb, MRTF-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:3050795
    NCBI Gene: 239719
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:13074345-13235393 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 9.24 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3050795
 protein coding gene Chr16:13073913-13235393 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022530
 protein coding gene Chr16:10209310-10380009 (+)
A/J MGP_AJ_G0022492
 protein coding gene Chr16:9639771-9814153 (+)
AKR/J MGP_AKRJ_G0022468
 protein coding gene Chr16:10079138-10242501 (+)
BALB/cJ MGP_BALBcJ_G0022496
 protein coding gene Chr16:9811933-9977805 (+)
C3H/HeJ MGP_C3HHeJ_G0022263
 protein coding gene Chr16:10160732-10328195 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022945
 protein coding gene Chr16:10377719-10549471 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020465
 protein coding gene Chr16:9748986-9911083 (+)
CAST/EiJ MGP_CASTEiJ_G0021790
 protein coding gene Chr16:10161438-10338115 (+)
CBA/J MGP_CBAJ_G0022232
 protein coding gene Chr16:10843048-11013153 (+)
DBA/2J MGP_DBA2J_G0022363
 protein coding gene Chr16:9644855-9809743 (+)
FVB/NJ MGP_FVBNJ_G0022339
 protein coding gene Chr16:9628841-9791974 (+)
LP/J MGP_LPJ_G0022431
 protein coding gene Chr16:10137132-10307860 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022361
 protein coding gene Chr16:10481092-10672575 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022958
 protein coding gene Chr16:10043082-10216968 (+)
PWK/PhJ MGP_PWKPhJ_G0021532
 protein coding gene Chr16:9902657-10066432 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021360
 protein coding gene Chr16:10032567-10198323 (+)
WSB/EiJ MGP_WSBEiJ_G0021838
 protein coding gene Chr16:10067324-10232567 (+)



Homology
more
  • Human Ortholog
    MRTFB, myocardin related transcription factor B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MRTFB, myocardin related transcription factor B
  • Synonyms
    MKL2, MRTF-B, NPD001
  • Links
    NCBI Gene ID: 57496
    neXtProt AC: NX_Q9ULH7
    UniProt: Q9ULH7

  • Chr Location
    16p13.12; chr16:13994774-14266779 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 5 alleles in 7 genetic backgrounds
    19 phenotypes from multigenic genotypes
    4 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out alleles exhibit prenatal lethality with widespread hemorrhaging, cardiovascular defects, and craniofacial anomalies. Mice homozygous for a gene trap allele exhibit fetal lethality due to cardiac outflow tractdefects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    95
  • cDNA Data
    73
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009569 Ensembl Gene Model | MGI Sequence Detail 161049 C57BL/6J ±  kb
    transcript ENSMUST00000009713 Ensembl | MGI Sequence Detail 5815 Not Applicable  
    polypeptide ENSMUSP00000009713 Ensembl | MGI Sequence Detail 1091 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 73
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36267, MGI:107691, MGI:3642211, MGI:6209746
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 11
      Phenotypes 30
    • Earliest
      J:1146 Skarnes WC, et al., A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes Dev. 1992 Jun;6(6):903-18
    • Latest
      J:351187 Khudayberdiev S, et al., The actin-binding protein CAP1 represses MRTF-SRF-dependent gene expression in mouse cerebral cortex. Sci Signal. 2024 May 7;17(835):eadj0032
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory