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Efnb2tm1Henk
Targeted Allele Detail
Summary
Symbol: Efnb2tm1Henk
Name: ephrin B2; targeted mutation 1, Mark Henkemeyer
MGI ID: MGI:3051214
Synonyms: B2lacZ, EB2/LZ, ephrin2lacZ, Ephrin-B2lacZ
Gene: Efnb2  Location: Chr8:8667434-8711242 bp, - strand  Genetic Position: Chr8, 3.42 cM
Alliance: Efnb2tm1Henk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91491
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The sequence encoding most of the cytoplasmic domain (amino acids 264-336) was replaced with an in-frame floxed lacZ cassette, and an frt-flanked PGK-neo. X-gal staining demonstrated LacZ was expressed in mutants. (J:91491)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 40 assay results
In Structures Affected by this Mutation: 20 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Efnb2 Mutation:  29 strains or lines available
References
Original:  J:91491 Dravis C, et al., Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev Biol. 2004 Jul 15;271(2):272-90
All:  27 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory