Unc13atm2Bros
Targeted Allele Detail
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| Symbol: |
Unc13atm2Bros |
| Name: |
unc-13 homolog A; targeted mutation 2, Nils Brose |
| MGI ID: |
MGI:3051217 |
| Synonyms: |
Munc13-1H567K |
| Gene: |
Unc13a Location: Chr8:72079356-72124418 bp, - strand Genetic Position: Chr8, 34.43 cM, cytoband B3.3
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| Alliance: |
Unc13atm2Bros page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:74347
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Hypomorph) |
| Mutation: |
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Nucleotide substitutions
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Mutation details: A knock-in strategy was used to insert an H567K point mutation. Crossing mice with EIIa-cre mice resulted in the removal of a floxed neo downstream of the exon containing the mutation. Southern blot and PCR confirmed recombination. Western blot indicated protein levels similar to that of wild-type.
(J:74347)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Unc13a Mutation: |
74 strains or lines available
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| Original: |
J:74347 Rhee JS, et al., Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell. 2002 Jan 11;108(1):121-33 |
| All: |
6 reference(s) |
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Analysis Tools
