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Psen1tm1Shs
Targeted Allele Detail
Summary
Symbol: Psen1tm1Shs
Name: presenilin 1; targeted mutation 1, Takuji Shirasawa
MGI ID: MGI:3051523
Synonyms: PS-1-
Gene: Psen1  Location: Chr12:83734926-83781869 bp, + strand  Genetic Position: Chr12, 38.84 cM
Alliance: Psen1tm1Shs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91975
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: The alternatively spliced variant of human Psen-1-374 and a tk-neo cassette were inserted into exon 9. Southern blot and PCR confirmed the mutant allele. Psen-1 mRNA was not detected by Northern blot analysis of mutant mice. Western blot detected no full length or truncated protein. (J:91975)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 38 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psen1 Mutation:  48 strains or lines available
References
Original:  J:91975 Yuasa S, et al., Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice. J Neurosci Res. 2002 Nov 1;70(3):501-13
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory