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Gja1tm1Gfi
Targeted Allele Detail
Summary
Symbol: Gja1tm1Gfi
Name: gap junction protein, alpha 1; targeted mutation 1, Glenn I Fishman
MGI ID: MGI:3051881
Synonyms: Cx43fl, Cx43flox
Gene: Gja1  Location: Chr10:56253297-56266519 bp, + strand  Genetic Position: Chr10, 28.64 cM
Alliance: Gja1tm1Gfi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91971
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A floxed neomycin resistance cassette was inserted into the single intron and a third loxP site was inserted in exon2 just downstream of the open reading frame. The targeting event did not affect gene expression. (J:91971)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gja1 Mutation:  60 strains or lines available
References
Original:  J:91971 Gutstein DE, et al., Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res. 2001 Feb 16;88(3):333-9
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory