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Hhattm2Ptch
Targeted Allele Detail
Summary
Symbol: Hhattm2Ptch
Name: hedgehog acyltransferase; targeted mutation 2, Pao-Tien Chuang
MGI ID: MGI:3051901
Synonyms: SkndeltaE9
Gene: Hhat  Location: Chr1:192195133-192453546 bp, - strand  Genetic Position: Chr1, 97.55 cM
Alliance: Hhattm2Ptch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89228
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation details: A loxP site was inserted upstream of exon 9 and a FRT-flanked PGK-neo downstream, with a loxP site at the most 3'end. Crossing with Cre-deleter mice excised the floxed sequence, removing exon 9 and the neo. Exon 9 contains predicted active sites for an acyltransferase. (J:89228)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hhat Mutation:  27 strains or lines available
References
Original:  J:89228 Chen MH, et al., Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004 Mar 15;18(6):641-59
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory