Ezrtm1Aim
Targeted Allele Detail
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| Symbol: |
Ezrtm1Aim |
| Name: |
ezrin; targeted mutation 1, Andrea I McClatchey |
| MGI ID: |
MGI:3052158 |
| Synonyms: |
Ez-, Ezdelta345-Betageo |
| Gene: |
Ezr Location: Chr17:7005530-7050179 bp, - strand Genetic Position: Chr17, 4.38 cM
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| Alliance: |
Ezrtm1Aim page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:92210
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| Parent Cell Line: |
J1 (ES Cell)
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| Strain of Origin: |
129S4/SvJae
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: LoxP sites were inserted to flank exons 3-5. An FRT-flanked promoterless Beta-galactosidase-neomycin cassette was inserted into intron 5. Crossing to EIIa-Cre mice excised the floxed region containing exons 3-5 and left the FRT-flanked Beta-geo. Immunohistochemical analysis of mutants confirmed absence of endogenous protein. Western blot of mutant neonate intenstinal tissue also demonstrated absence of protein.
(J:92210)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ezr Mutation: |
87 strains or lines available
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| Original: |
J:92210 Saotome I, et al., Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev Cell. 2004 Jun;6(6):855-64 |
| All: |
2 reference(s) |
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Analysis Tools
