Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Vil1-cre/ERT2)23Syr
Name:	transgene insertion 23, Sylvie Robine
MGI ID:	MGI:3053826
Synonyms:	TgvCreERT2, Tg(Vil-cre/ESR1)23Syr, vil-Cre-ERT2, vil-Cre-ERT2, villin-creERT2, villin::CreERT2, Villin-Cre(ER-T2), Villin-CreERT2
Transgene:	Tg(Vil1-cre/ERT2)23Syr  Location: unknown
Alliance:	Tg(Vil1-cre/ERT2)23Syr page

Strain of Origin:

(C57BL/6 x DBA/2)

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Vil1-cre/ERT2)23Syr expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Vil1 (MGI:98930)   Mutation details: A 9 kb segment of the regulatory region of the mouse Vil gene drives expression of cre recombinase fused to a mutated ligand-binding domain of the human estrogen receptor. Cre recombination is inducible with tamoxifen treatment in epithelial cells all along the crypt-villus axis and in undifferentiated progenitor cells in the crypt region. This is a representative record for the two lines generated (Fo23 and Fo24) that have the same inducible expression pattern. Only 1 copy of the transgene is integrated into these lines. (J:92295)

Activity:	Tissue activity of this recombinase allele
Driver:	Vil1 (mouse) Summary of all recombinase alleles driven by Vil1. Comparative matrix view of recombinase activities Alliance mouse Vil1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

List all tumor models in MMHCdb carrying Tg(Vil1-cre/ERT2)23Syr

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:92295 el Marjou F, et al., Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis. 2004 Jul;39(3):186-93
All:	450 reference(s)