Shh<tm1(EGFP/cre)Cjt> Targeted Allele Detail MGI Mouse (MGI:3053959)

Shh^{tm1(EGFP/cre)Cjt}
Targeted Allele Detail

Summary

Symbol:	Shh^{tm1(EGFP/cre)Cjt}
Name:	sonic hedgehog; targeted mutation 1, Clifford J Tabin
MGI ID:	MGI:3053959
Synonyms:	Shh-cre, Shh^CreEGFP, Shh^cre/Gfp, Shh^gfpcre, Shhgfpcre, Shhgfp-Cre, Shh-GFP-Cre, Shh^GFP-Cre
Gene:	Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
Alliance:	Shh^{tm1(EGFP/cre)Cjt} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:92504
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:

Targeted (Null/knockout, Recombinase)

Mutations:

Insertion, Intragenic deletion

Shh^{tm1(EGFP/cre)Cjt} expression driven by 1 gene

Mutation details: A cassette containing an in frame fusion between GFP and cre was inserted at the ATG. Upon recombination, the first 35 base pairs after the ATG were deleted. Fluorescence was detected in the distal posterior region of E10-E12 embryos. (J:92504)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Shh (mouse) Summary of all recombinase alleles driven by Shh. Comparative matrix view of recombinase activities Alliance mouse Shh gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	712 assay results 41 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Shh Mutation:	48 strains or lines available

References

Original:	J:92504 Harfe BD, et al., Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 2004 Aug 20;118(4):517-28
All:	297 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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