Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Shhtm2(cre/ERT2)Cjt
Name:	sonic hedgehog; targeted mutation 2, Clifford J Tabin
MGI ID:	MGI:3053960
Synonyms:	Shh-cre, ShhCreER, ShhCreER, ShhcreERT2, ShhcreERT2, ShhCreERT2, ShhCreesr, Shhtm2(cre-ERT2)Cjt, Shhtm2(cre/ESR1)Cjt
Gene:	Shh  Location: Chr5:28661838-28672099 bp, - strand  Genetic Position: Chr5, 14.39 cM
Alliance:	Shhtm2(cre/ERT2)Cjt page

Germline Transmission:	Earliest citation of germline transmission: J:92504
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Shhtm2(cre/ERT2)Cjt expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Shh (MGI:98297)   Mutation details: A cassette containing CreERT2 was inserted at the ATG. Upon recombination, the first 35 base pairs after the ATG were deleted. Cre was produced in all cells in which the endogenous mRNA was normally expressed. (J:92504)

Activity:	Tissue activity of this recombinase allele
Driver:	Shh (mouse) Summary of all recombinase alleles driven by Shh. Comparative matrix view of recombinase activities Alliance mouse Shh gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

5 assay results

List all tumor models in MMHCdb carrying Shhtm2(cre/ERT2)Cjt

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shh Mutation:	48 strains or lines available

Original:	J:92504 Harfe BD, et al., Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 2004 Aug 20;118(4):517-28
All:	120 reference(s)