Cdk6<tm1Bbd> Targeted Allele Detail MGI Mouse (MGI:3053975)

Cdk6^tm1Bbd
Targeted Allele Detail

Summary

Symbol:	Cdk6^tm1Bbd
Name:	cyclin dependent kinase 6; targeted mutation 1, Mariano Barbacid
MGI ID:	MGI:3053975
Synonyms:	Cdk6^-
Gene:	Cdk6 Location: Chr5:3391485-3581008 bp, + strand Genetic Position: Chr5, 2.04 cM, cytoband A2-A3
Alliance:	Cdk6^tm1Bbd page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:92529
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A PGK-neo cassette replaced the first coding exon, which contains the ATG as well as the PLSTIRE domain essential for cyclin binding. PCR confirmed recombination in mutant mice. Immunohistochemical analysis of lymphocytes indicated lack of protein expression in mutants. (J:92529)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Cdk6 Mutation:	40 strains or lines available

References

Original:	J:92529 Malumbres M, et al., Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell. 2004 Aug 20;118(4):493-504
All:	19 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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