Prnp<tm1Ito> Targeted Allele Detail MGI Mouse (MGI:3054245)

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Prnp^tm1Ito
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Prnp^tm1Ito
Name:	prion protein; targeted mutation 1, Shigeyoshi Itohara
MGI ID:	MGI:3054245
Synonyms:	Prnp-, Prnp⁰, Rikn Prnp-
Gene:	Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
Alliance:	Prnp^tm1Ito page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:68801
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A PGK-neomycin resistance cassette replaced the gene open reading frame and the 3' end of intron 2. Western analysis of lysates from cerebra did not detect protein. (J:68801)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Prnp Mutation:	142 strains or lines available

References

Original:	J:68801 Yokoyama T, et al., In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies. J Biol Chem. 2001 Apr 6;276(14):11265-71
All:	11 reference(s)

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