Grin2c<tm1Mwa> Targeted Allele Detail MGI Mouse (MGI:3054830)

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Grin2c^tm1Mwa
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Grin2c^tm1Mwa
Name:	glutamate receptor, ionotropic, NMDA2C (epsilon 3); targeted mutation 1, Masahiko Watanabe
MGI ID:	MGI:3054830
Synonyms:	GluRepsilon3^-
Gene:	Grin2c Location: Chr11:115139995-115158069 bp, - strand Genetic Position: Chr11, 80.8 cM
Alliance:	Grin2c^tm1Mwa page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:89405
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance gene replaced the exon encoding the transmembrane segment M4. In situ hybridization confirmed the absence of mRNA in mutant brains. (J:92648)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Grin2c Mutation:	56 strains or lines available

References

Original:	J:92648 Abe M, et al., NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. J Neurosci. 2004 Sep 18;24(33):7292-304
All:	3 reference(s)

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