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Myf5tm2Tajb
Targeted Allele Detail
Summary
Symbol: Myf5tm2Tajb
Name: myogenic factor 5; targeted mutation 2, Shahragim Tajbakhsh
MGI ID: MGI:3055343
Synonyms: Myf5loxP
Gene: Myf5  Location: Chr10:107318769-107321995 bp, - strand  Genetic Position: Chr10, 55.95 cM
Alliance: Myf5tm2Tajb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92799
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A targeting vector was designed to delete the amino-terminal domain following cre-mediated recombination, leaving a single loxP site upstream of the basic helix-loop-helix domain. The endogenous ATG was mutated to GTG, leaving the first ATG codons suitable for translation located in the chromatin remodeling and basic domains, at residues 69 and 82, respectively. This alleles was generated from Myf5tm3Tajb. (J:92799)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myf5 Mutation:  17 strains or lines available
References
Original:  J:92799 Kassar-Duchossoy L, et al., Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice. Nature. 2004 Sep 23;431(7007):466-71
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory